Essential details
MOQ:1
G.W:28 kg
Lead time:2-3
N.W:25 kg
Shipping:Express Delivery, Air freight, Ocean freight
Specification Number:99%
Package Description:内PE袋， 外纸桶
Product Introduction
Introduction to NMNH (Reduced Nicotinamide Mononucleotide) in Cosmetics
NMNH (Reduced Nicotinamide Mononucleotide), also known as β-Nicotinamide Mononucleotide (reduced form), is a biologically active compound derived from nicotinamide adenine dinucleotide (NAD⁺), a coenzyme critical for cellular energy metabolism and DNA repair. In cosmetics, NMNH has gained attention for its potential anti-aging, antioxidant, and skin-rejuvenating properties. Below is an overview of its role in cosmetic formulations:
1. Key Properties & Benefits
- Antioxidant Activity: NMNH neutralizes free radicals, protecting the skin from oxidative stress caused by environmental factors (e.g., UV radiation, pollution), which contributes to premature aging and dullness.
- Anti-Aging Effects: By replenishing intracellular NAD⁺ levels, NMNH supports cellular energy production (mitochondrial function) and activates sirtuins (enzymes linked to longevity), promoting collagen synthesis and reducing fine lines/wrinkles.
- Skin Barrier Enhancement: It improves skin hydration and elasticity by supporting keratinocyte differentiation and lipid biosynthesis, addressing dryness and restoring the skin’s protective barrier.
- Cellular Repair & Regeneration: NMNH accelerates DNA repair mechanisms, aiding in post-inflammatory skin recovery and reducing the appearance of damage (e.g., hyperpigmentation, uneven texture).
2. Mechanism of Action
NMNH acts as a direct precursor to NAD⁺, bypassing rate-limiting steps in its biosynthesis. Topical application allows NMNH to penetrate the skin (via passive diffusion or carrier systems), where it is converted to NAD⁺. Elevated NAD⁺ levels:
- Activate sirtuins (SIRT1-SIRT7), regulating gene expression for anti-aging and stress resistance.
- Fuel cellular processes (e.g., glycolysis, citric acid cycle) essential for skin health and renewal.
- Support the Nrf2 pathway, enhancing antioxidant defenses and detoxification.
3. Cosmetic Applications
- Formulations: Commonly found in serums, creams, masks, and anti-aging treatments.
- Target Skin Concerns: Aging (wrinkles, loss of elasticity), dryness, oxidative damage, uneven tone, and post-acne scarring.
- Synergistic Ingredients: Often paired with hyaluronic acid (hydration), retinol (collagen stimulation), peptides (firming), and antioxidants (e.g., vitamin C, resveratrol) for enhanced efficacy.
4. Safety & Stability
- Non-Irritating: Generally well-tolerated by most skin types; suitable for sensitive skin when formulated appropriately.
- Stability: The reduced form (NMNH) is more stable than the oxidized form (NMN) in cosmetic matrices, resisting degradation from light and heat.
- Clinical Support: Studies suggest topical NMNH improves skin hydration, elasticity, and texture without significant side effects (source: preclinical and observational data).
5. Future Trends
Research explores NMNH’s potential in:
- Photoaging prevention (protection against UV-induced damage).
- Microbiome modulation (supporting skin microbial balance).
- Transdermal delivery systems (liposomes, nanocarriers) to enhance penetration and bioavailability.
Conclusion
NMNH represents a promising ingredient in cosmeceuticals, merging scientific understanding of NAD⁺ biology with skincare innovation. Its ability to boost cellular energy, combat oxidation, and promote rejuvenation positions it as a key component in next-generation anti-aging formulations. As formulations evolve, NMNH is likely to become a staple in premium skincare targeting holistic skin health.
References:
- Preclinical studies on NAD⁺ precursors in dermatology (e.g., Journal of Cosmetic Dermatology).
- Cosmetic ingredient databases (INCID: pending; CAS: 1094-61-7 for NMN, reduced form specifics may vary).
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